小畠 りか
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- 分野 :
- 化学
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- E-mail :
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- 専門 :
- 天然物化学・創薬化学・ケミカルバイオロジー
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- 学歴 :
- 博士(理学)
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- 所属学会 :
- 日本化学会,日本薬学会,American Chemical Society
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- 担当教科 :
- 経済学部 (Science and environment I, Chemistry for life sciences),理工学部(自然科学実験),法学部(自然科学特論 I, II)
主要論文
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Higashi T, Yoshida C, Hachiro Y, Nakata C, Takechi A, Yagi T, Miyashita K, Kitada N, Obata R, Hirano T, Hara T, Maki SA. (2023) Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus. Bioorg. Med. Chem. Lett.95:129471
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Ryohei Saito-Moriya, Jun Nakayama, Genta Kamiya, Nobuo Kitada, Rika Obata, Shojiro A. Maki, Hiroshi Aoyama (2021) How to select firefly luciferin analogues for in vivo imaging. Int. J. Mol. Sci.22 (4): 1848
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T. Saito, Y. Ichimura, K. Taguchi, T. Suzuki, T. Mizushima, K. Takagi, Y. Hirose, M. Nagahashi, T. Iso, T. Fukutomi, M. Ohishi, K. Endo, T. Uemura, Y. Nishito, S. Okuda, M. Obata, T. Kouno, R. Imamura, Y. Tada, R. Obata, D. Yasuda, K. Takahashi, T. Fujimura, J. Pi, M.-S. Lee, T. Ueno, T. Ohe, T. Mashino, T. Wakai, H. Kojima, T. Okabe, T. Nagano, H. Motohashi, S. Waguri, T. Soga, M. Yamamoto, K. Tanaka, M. Komatsu (2016) p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun7: 12030
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M. Kiyama, R. Saito, S. Iwano, R. Obata, H. Niwa, S. A. Maki, (2016) Multicolor bioluminescence obtained using firefly luciferin. Curr Top Med Chem16(24):2648-2655
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Taiki Kojima, Rika Obata, Tsuyoshi Saito, Yasuaki Einaga, Shigeru Nishiyama (2015) Cathodic reductive coupling of methyl cinnamate on boron-doped diamond electrodes and synthesis of new neolignan-type products. Beilstein J. Org. Chem.11: 200-203
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R. Obata, S. Ohba, Y. Einaga & S. Nishiyama (2015) Crystal structure of 5,5′-dibromo-3,3′-di-tert-butyl-6,6′-dimethylbiphenyl-2,2′-diol. Acta CrystE71: o278-o279
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向井知大、 小畠りか、 大場茂(2012) 「無電解めっきとフォトレジストを用いた鏡の作成」 慶應義塾大学日吉紀要、自然科学No.52, 19-35
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小畠りか, 向井知大, 大場茂(2011) 中和滴定と酸塩基指示薬の可視吸収スペクトル 慶應義塾大学日吉紀要 自然科学50: 77-102
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向井知大, 小畠りか, 大場茂(2011) アセトアニリドの合成の実験条件とアニリンブラック 慶應義塾大学日吉紀要 自然科学50: 61-75
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Obata R., Nakasako M. (2010) Structural basis for inverting the enantioselectivity of arylmalonate decarboxylase revealed by the structural analysis of the Gly74Cys/Cys188Ser mutant in the liganded form Biochemistry 49(9): 1963-1969
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Saitoh T., Shimada C., Takeiri M., Shiino M., Ohba S., Obata R., Ishikawa Y., Umezawa K., Nishiyama S. (2010) A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ. Bioorg Med Chem Lett20 (19): 5638-5642
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Ishikawa Y., Tachibana M., Matsui C., Obata R., Umezawa K., Nishiyama S. (2009) Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB. Bioorg Med Chem Lett 19 (6): 1726-1728
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Saitoh T., Suzuki E., Takasugi A., Obata R., Ishikawa Y., Umezawa K., Nishiyama S. (2009) Efficient synthesis of (±)-parasitenone, a novel inhibitor of NF-kB. Bioorg Med Chem Lett19(18): 5383-5386
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Nakasako M., Obata R., Okubo R., Nakayama S., Miyamoto K., Ohta H. (2008) Crystallization and preliminary X-ray diffraction experiments of arylmalonate decarboxylase from Alcaligenes bronchisepticus. ACTA Crystallogr Sect F Struct Biol Cryst Commun 64(Pt7): 610-613
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Fujino A., Asano M., Yamaguchi H., Shirasaka N., Sakoda A.,Ikunaka M., Obata R., Nishiyama S., Sugai T. (2007) Bacillus subtilis epoxide hydrolase-catalyzed preparation of enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-bicalutamide. Tetrahedron Lett48(6): 979-983
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Hiraoka C., Matsuda M., Suzuki Y., Fujieda S., Tomita M., Fushuku K., Obata R., Nishiyama S., Sugai T. (2007) Screening, substrate specificity and stereoselectivity of yeast strains, which reduce sterically hindered isopropyl ketones. Tetrahedron: Asymmetry 17: 3358-3367
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Shiina J., Oikawa M., Nakamura K., Obata R., Nishiyama S. (2007) Synthesis of pinguisane-type sesquiterpenoids acutifolone A, pinguisenol, and bisacutifolones by a Diels-Alder dimerization reaction. Eur J Org Chem 2007 (31): 5190-5197