おばた　りか

Rika OBATA

Ph. D. (Science)
  • Research Field :
    Chemistry
  • Specific Research Topic :
    Natural products, Drug design

Selected Journal Publications

  1. Higashi T, Yoshida C, Hachiro Y, Nakata C, Takechi A, Yagi T, Miyashita K, Kitada N, Obata R, Hirano T, Hara T, Maki SA. (2023) Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus. Bioorg. Med. Chem. Lett.95:129471 doi

  2. Ryohei Saito-Moriya, Jun Nakayama, Genta Kamiya, Nobuo Kitada, Rika Obata, Shojiro A. Maki, Hiroshi Aoyama (2021) How to select firefly luciferin analogues for in vivo imaging. Int. J. Mol. Sci.22 (4): 1848 doi

  3. T. Saito, Y. Ichimura, K. Taguchi, T. Suzuki, T. Mizushima, K. Takagi, Y. Hirose, M. Nagahashi, T. Iso, T. Fukutomi, M. Ohishi, K. Endo,　T. Uemura, Y. Nishito, S. Okuda, M. Obata, T. Kouno, R. Imamura,　Y. Tada, R. Obata, D. Yasuda, K. Takahashi, T. Fujimura, J. Pi, M.-S. Lee, T. Ueno, T. Ohe, T. Mashino, T. Wakai,　H. Kojima, T. Okabe, T. Nagano, H. Motohashi, S. Waguri, T. Soga,　M. Yamamoto, K. Tanaka, M. Komatsu (2016) p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun7: 12030 doi

  4. M. Kiyama, R. Saito, S. Iwano, R. Obata, H. Niwa, S. A. Maki, (2016) Multicolor bioluminescence obtained using firefly luciferin. Curr Top Med Chem16(24):2648-2655 doi

  5. Taiki Kojima, Rika Obata, Tsuyoshi Saito, Yasuaki Einaga, Shigeru Nishiyama (2015) Cathodic reductive coupling of methyl cinnamate on boron-doped diamond electrodes and synthesis of new neolignan-type products. Beilstein J. Org. Chem.11: 200-203 doi

  6. R. Obata, S. Ohba, Y. Einaga & S. Nishiyama (2015) Crystal structure of 5,5′-dibromo-3,3′-di-tert-butyl-6,6′-dimethylbiphenyl-2,2′-diol. Acta CrystE71: o278-o279 doi

  7. 向井知大、 小畠りか、 大場茂(2012) 「無電解めっきとフォトレジストを用いた鏡の作成」 慶應義塾大学日吉紀要、自然科学No.52, 19-35 関連リンク

  8. 小畠りか， 向井知大， 大場茂(2011) 中和滴定と酸塩基指示薬の可視吸収スペクトル 慶應義塾大学日吉紀要　自然科学50: 77-102 関連リンク

  9. 向井知大， 小畠りか， 大場茂(2011) アセトアニリドの合成の実験条件とアニリンブラック 慶應義塾大学日吉紀要　自然科学50: 61-75

  10. Obata R., Nakasako M. (2010) Structural basis for inverting the enantioselectivity of arylmalonate decarboxylase revealed by the structural analysis of the Gly74Cys/Cys188Ser mutant in the liganded form Biochemistry 49(9): 1963-1969 doi

  11. Saitoh T., Shimada C., Takeiri M., Shiino M., Ohba S., Obata R., Ishikawa Y., Umezawa K., Nishiyama S. (2010) A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ. Bioorg  Med  Chem Lett20 (19): 5638-5642 doi

  12. Ishikawa Y., Tachibana M., Matsui C., Obata R., Umezawa K., Nishiyama S. (2009) Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB. Bioorg Med Chem Lett 19 (6): 1726-1728 doi

  13. Saitoh T., Suzuki E., Takasugi A., Obata R., Ishikawa Y., Umezawa K., Nishiyama S. (2009) Efficient synthesis of (±)-parasitenone, a novel inhibitor of NF-kB. Bioorg Med Chem Lett19(18): 5383-5386 doi

  14. Nakasako M., Obata R., Okubo R., Nakayama S., Miyamoto K., Ohta H. (2008) Crystallization and preliminary X-ray diffraction experiments of arylmalonate decarboxylase from Alcaligenes bronchisepticus. ACTA Crystallogr Sect F Struct Biol Cryst Commun 64(Pt7): 610-613 doi

  15. Fujino A., Asano M., Yamaguchi H., Shirasaka N., Sakoda A.,Ikunaka M., Obata R., Nishiyama S., Sugai T. (2007) Bacillus subtilis epoxide hydrolase-catalyzed preparation of enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-bicalutamide. Tetrahedron Lett48(6): 979-983 doi

  16. Hiraoka C., Matsuda M., Suzuki Y., Fujieda S., Tomita M., Fushuku K., Obata R., Nishiyama S., Sugai T. (2007) Screening, substrate specificity and stereoselectivity of yeast strains, which reduce sterically hindered isopropyl ketones. Tetrahedron: Asymmetry 17: 3358-3367 doi

  17. Shiina J., Oikawa M., Nakamura K., Obata R., Nishiyama S. (2007) Synthesis of pinguisane-type sesquiterpenoids acutifolone A, pinguisenol, and bisacutifolones by a Diels-Alder dimerization reaction. Eur J Org Chem 2007 (31): 5190-5197 doi

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