ふるかわ　りょうへい

Ryohei FURUKAWA

Ph.D.
  • Research Field :
    Biology
  • Specific Research Topic :
    Developmental Biology & Immunobiology

Research Description

Immune system of the starfish

Selected Journal Publications

  1. Kiyono, S., Miyashita, S., Yamaguchi, K., Saito, I., Saito, Y., Manta, S., Ishikawa, M., Natira, M., Watanabe, T., Ito, R., Taguchi, M., Furukawa, R., Ikeuchi, A., Matsuo, K., Kurita, G., Kumagai, T., Shirakashi, S., Ogawa, K., Sakamoto, K., Koyanagi, R., Satoh, N., Sasaki, M., Maezawa, T., Ichikawa-Seki, M., Kobayashi, K. (2023) Sex-inducing effects toward planarians widely present among parasitic flatworms. iScience26:105776 doi

  2. Taguchi, M.*, Minakata, K., Tame, A., Furukawa, R.* (2022) Establishment of the immunological self in juvenile Patiria pectinifera post-metamorphosis. Front Immunol. (*Co-corresponding authors) Front Immunol13:1056027 doi

  3. Komaki, S., Ohmomo, H., Hachiya, T., Sutoh, Y., Ono, K., Furukawa, R., Umekage, S., Otsuka-Yamasaki, Y., Minabe, S., Takashima, A., Tanno, K., Sasaki, M., Shimizu, A. (2022) Evaluation of short-term epigenetic age fluctuation. Clin Epigenet14:76 doi

  4. Komaki, S., Ohmomo, H., Hachiya, T., Sutoh Y., Ono, K., Furukawa, R., Umekage, S., Otsuka-Yamasaki, Y., Tanno, K., Sasaki, M., Shimizu. A. (2021) Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics. Clin Epigenet13: 219 doi

  5. Maezawa, T., Ishikawam M., Sekii, K., Nagamatsu, G., Furukawa, R., Kobayashi, K. (2021) D-Tryptophan enhances the reproductive organ-specific expression of the amino acid transporter homolog Dr-SLC38A9 involved in the sexual induction of the planarian Dugesia ryukyuensis. Zoological Lett7: 4 doi

  6. Yamazki, A., Morino, Y., Urata, M., Yamaguchi, M., Minokawa, T., Furukawa, R., Kondo, M., Wada, H. (2020) pmar1/phb homeobox genes and the evolution of the double-negative gate for endomesoderm specification in echinoderms. Development147. dev182139. doi

  7. Sekii, K., Yorimoto, S., Okamoto, H., Nagao, N., Maezawa, T., Matsui, Y., Yamaguchi, K., Furukawa, R., Shigenobu, S., Kobayashi, K. (2019) Transcriptomic analysis reveals differences in the regulation of amino acid metabolism in asexual and sexual planarians. Sci Rep9. 6132. doi

  8. 古川亮平(2018) マクロファージの起源 日本動物学会編 『動物学の百科事典』, 丸善出版502-503 関連リンク

  9. Smith, LC., Arriza, V., Barela Hudgell, MA., Barone, G., Bodnar, AG., Buckley, KM., Cunsolo, V., Dheilly, N., Franchi, N., Fugmann, SD., Furukawa, R., Garcia-Arraras, J., enson, JH., Hibino, T., Irons, ZH., Li, C., Lun, CM., Majeske, AJ., Oren, M., Pagliara, P., Pinsino, A., Raftos, DA., Rast, JP., Samasa, B., Schillaci, D., Schrankel, CS., Stabili, L., Stensväg, K., Sutton, E. (2018) Echinodermata: The Complex Immune System in Echinoderms. In “Advances in Comparative Immunology”, EL Cooper, ed. Springer Publisher409-501 doi

  10. Komaki, S., Shiwa, Y., Furukawa, R., Hachiya, T., Ohmomo, H., Otomo, R., Satoh, M., Hitomi, J., Sobue, K., Sasaki, M., Shimizu, A. (2018) iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation. Human Genome Variation5:18008 doi

  11. Komaki, S., Ohmomo, H., Hachiya, T., Furukawa, R., Shiwa, Y., Satoh, M., Endo, R., Doita, M., Sasaki, M., Shimizu, A. (2017) An epigenome-wide association study based on cell type-specific whole-genome bisulfite sequencing: Screening for DNA methylation signatures associated with bone mass. Integr Mol Med4(5): 1-7 pdf

  12. Saito, S., Hamanaka, G., Kawai, N., Furukawa, R., Gojobori, J., Tominaga, M., Kaneko, H.Satta, Y. (2017) Characterization of TRPA channels in the starfish Patiria pectinifera: involvement of thermally activated TRPA1 in thermotaxis in marine planktonic larvae. Sci Rep7: 2173 doi

  13. Hachiya, T., Furukawa, R., Shiwa, Y., Ohmomo, H., Ono, K., Katsuoka, F., Nagasaki, M., Yasuda, J., Fuse, N., Kinoshita, K., Yamamoto, M., Tanno, K., Satoh, M., Endo, R., Sasaki, M., Sakata, K., Kobayashi, S., Ogasawara, K., Hitomi, J., Sobue, K., Shimizu, A. (2017) Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies. npj Genomic Medicine2: 11 doi

  14. Hachiya, T., Kamatani, Y., Takahashi, A., Hata, J., Furukawa, R., Shiwa, Y., Yamaji, T., Hara, M., Tanno, K., Ohmomo, H., Ono, K., Takashima, N., Matsuda, K., Wakai, K., Sawada, N., Iwasaki, M., Yamagishi, K., Ago, T., Ninomiya, T., Fukushima, A., Hozawa, A., Minegishi, N., Satoh, M., Endo, R., Sasaki, M., Sakata, K., Kobayashi, S., Ogasawara, K., Nakamura, M., Hitomi, J., Kita, Y., Tanaka, K., Iso, H., Kitazono, T., Kubo, M., Tanaka, H., Tsugane, S., Kiyohara, Y., Yamamoto, M., Sobue, K., Shimizu, A. (2017) Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. Stroke48: 253-258 doi

  15. Furukawa, R., Hachiya T., Ohmomo H., Shiwa Y., Ono K., Suzuki S., Satoh M., Hitomi J., Sobue K. and Shimizu A. (2016) Intraindividual dynamics of transcriptome and genome-wide stability of DNA methylation. Sci Rep6. 26424 doi

  16. Furukawa R., Tamaki K., Kaneko H.(2016) Two macrophage migration inhibitory factors regulate starfish larval immune cell chemotaxis. Immunol Cell Biol94(4): 315-321 関連リンク

  17. Shiwa Y., Hachiya T., Furukawa R., Ohmomo H., Ono K., Kudo H., Hata J., Hozawa A., Iwasaki M., Matsuda K., Minegishi N., Satoh M., Tanno K., Yamaji T., Wakai K., Hitomi J., Kiyohara Y., Kubo M., Tanaka H., Tsugane S., Yamamoto M., Sobue K., Shimizu A. (2016) Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols. PLoS ONE11. e0147519 doi

  18. 古川亮平, 清水厚志 (2016) IMMオミックスレファレンスパネルの取り組み． 生化学88: 36-43 doi

  19. 大桃秀樹, 古川亮平, 清水厚志 (2016) ヒト血液検体のトランスクリプトーム解析. 実験医学別冊 RNA-Seq実験ハンドブック　羊土社74-82 (ISBN 978-4-7581-0194-3) 関連リンク

  20. 古川亮平, 八谷剛史, 清水厚志 (2016) 全エピゲノム関連解析（EWAS）. 金井弥栄編. 実験医学増刊 エピゲノム研究 修飾の全体像の理解から先制・個別化医療へ　羊土社,76-82 (ISBN 978-4-7581-0355-8) 関連リンク

  21. Ohmomo, H., Hachiya, T., Shiwa, Y., Furukawa, R., Ono, K, Ito, S., Ishida, Y., Satoh, M., Hitomi, J., Sobue, K., Shimizu, A. (2014) Reduction of systematic bias in transcriptome data from human peripheral blood mononuclear cells for transportation and biobanking. PLoS ONE9. e104283 doi

  22. Kawase, O., Furukawa, R.(2014) Regional difference of ray number variation in a starfish, Patiria pectinifera. Annual Report of Premedical Sciences, Dokkyo Medical University3: 49-52 関連リンク

  23. Furukawa, R., Matsumoto, M., Kaneko, H.(2012) Characterization of a scavenger receptor cysteine-rich-domain-containing protein of the starfish, Asterina pectinifera: ApSRCR1 acts as an opsonin in the larval and adult innate immune systems. Developmental & Comparative Immunology36: 51-61 doi

  24. Furukawa, R., Funabashi, H., Matsumoto, M., Kaneko, H.(2012) Starfish ApDOCK protein essentially functions in larval defense system operated by mesenchyme cells. Immunology & Cell Biology90: 955-965 関連リンク

  25. 古川亮平(2009) ヒトデ幼生に探るマクロファージのご先祖① メチニコフの発見から１００年 ミクロスコピア26(1): 9-16 関連リンク

  26. 古川亮平(2009) ヒトデ幼生に探るマクロファージのご先祖② 自己と非自己をさかのぼって考える ミクロスコピア26(2): 98-102 関連リンク

  27. Furukawa R., Takahashi Y., Nakajima Y., Dan-Sohkawa M. and Kaneko H. (2009) Defense system by mesenchyme cells in bipinnaria larvae of the starfish, Asterina pectinifera. Dev Comp Immunol33(2): 205-215 doi

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