Koji IOKU

Research Description

Microstructural Design of Ceramic Scaffolds
Preparation of Tailored Ceramics for Regenerative Medicine
Analysis of Leadership in Science and Technology

Selected Journal Publications

1. Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku  (2019) Adhesion Behavior of Microorganisms Isolated from Soil on Hydroxyapatite and Other Materials. Appl Biochem Biotechnol 187：984-993

    

2. Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku  (2018) Preparation of spherical porous hydroxyapatite granules as support materials for microorganisms.   J Ceram Soc Japan 126 (9): 732-735

    

3. Kenshiro Kimura, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku  (2018) Formation Process of Hydroxyapatite Granules in Agarose Hydrogel by Electrophoresis.   Cryst Growth Des 18 (4): 1961-1966

    

4. 井奥洪二, 上高原理暢 (Koji Ioku, Masanobu Kamitakahara) (2017) バイオセラミックスとしてのリン酸カルシウム多孔体 (Calcium Phosphates Porous Bioceramics.)  Phosphorus Letter 88: 381-390

    

5. Kota Morishita, Eri Tatsukawa, Yasuaki Shibata, Fumio Suehiro, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku, Masahiro Umeda, Masahiro Nishimura, Tohru Ikeda (2016) Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model.  Acta Biomaterialia 39: 180-191

    

6. Masanobu Kamitakahara, Eri Tatsukawa, Yasuaki Shibata, Shota Umemoto, Taishi Yokoi, Koji Ioku, Tohru Ikeda (2016) Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics.  J Mater Sci: Mater Med 27:97

    

7. Masanobu Kamitakahara, Naohiro Ohtoshi, Masakazu Kawashita, Koji Ioku (2016) Spherical porous hydroxyapatite granules containing composites of magnetic and hydroxyapatite nanoparticles for the hyperthermia treatment of bone tumor.  J Mater Sci: Mater Med 27:93

    

8. Hehe Guo, Huaijuan Zhou, Ping Jin, Wenjing Li, Yining Ma, Ioku Koj, Shidong Ji (2016) Hydrothermal-assisted biomimetic synthesis of brush-like Hap/PAN composite and its application for decontaminating the metal ions. RSC Advances 6: 5965-5972

    

9. Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku (2016) Adhesion behaviors of Escherichia coli on hydroxyapatite Mater. Sci. Eng. C 61: 169-173

    

10. Masanobu Kamitakahara, Takuya Nagamoria, Taishi Yokoia, Koji Ioku (2015) Carbonate-containing hydroxyapatite synthesized by the hydrothermal treatment of different calcium carbonates in a phosphate-containing solution J. Asian Ceram. Soc. 3: 287-291

     

11. Natsuko Ito, Masanobu Kamitakahara, Koji Ioku (2014) Preparation and evaluation of spherical porous granules of octacalcium phosphate/hydroxyapatite as drug carriers in bone cancer treatment. Mater. Lett. 120: 94-96

     

12. Masanobu Kamitakahara, Yuika Uno, Koji Ioku (2014) Behavior of osteoblast-like cells on calcium-deficient hydroxyapatite ceramics composed of particles with different shapes and sizes. J Mater Sci: Mater Med 25: 239–245

     

13. Tohru Ikeda, Michiyuki Kasai, Eri Tatsukawa, Masanobu Kamitakahara, Yasuaki Shibata, Taishi Yokoi, Takayuki K. Nemoto, Koji Ioku (2014) A bone substitute with high affinity for vitamin D-binding protein ― relationship with niche of osteoclasts. J. Cell. Mol. Med. 18 [1]: 170-180

     

14. Eri Tatsukawa, Yoshinori Gonda, Masanobu Kamitakahara, Masaaki Matsuura, Masaru Ushijima, Yasuaki Shibata, Ikuho Yonezawa, Mutsunori Fujiwara, Koji Ioku, Tohru Ikeda (2014) Promotion of normal healing of bone defects under estrogen deficiency by implantation of beta-tricalcium phosphate composed of rod-shaped particles. J. Orthopaedic Res. 32 [2]: 189-196

     

15. Natsuko Ito, Masanobu Kamitakahara, Koji Ioku (2013) Observation of transformation behavior of octacalcium phosphate to hydroxyapatite. Key Eng. Mater. 529-530: 11-14

     

16. Masanobu Kamitakahara, Shota Umemoto, Koji Ioku (2013) Characterization and in vitro evaluation of silicate-containing tricalcium phosphate prepared through wet chemical process. Key Eng. Mater. 529-530: 105-108

     

17. Masanobu Kamitakahara, Ryohei Imai, Koji Ioku (2013) Preparation and evaluation of spherical Ca-deficient hydroxyapatite granules with controlled surface microstructure as drug carriers. Mater. Sci. Eng. C 33: 2446–2450

     

18. Masanobu Kamitakahara, Hiroko Takahashi, Koji Ioku (2012) Tubular hydroxyapatite formation through a hydrothermal process from α-tricalcium phosphate with anatase. J. Mater. Sci. 47: 4194-4199

     

19. M Kamitakahara, T Saito and K Ioku (2012) Synthesis and in vitro evaluation of hydroxyapatite with controlled morphology. Journal of Physics: Conference Series 339: 012002

     

20. Natsuko Ito, Masanobu Kamitakahara and Koji Ioku (2012) Preparation of spherical granules of octacalcium phosphate for medical application. Functional Mater. Lett. 5 [2]: 1260009-1-3

     

21. Masanobu Kamitakahara, Kenshiro Kimura, Koji Ioku  (2012) Synthesis of nanosized porous hydroxyapatite granules in hydrogel by electrophoresis. Colloids and Surfaces B: Biointerfaces 97: 236-239

     

22. Jumpei Hayashi1, Masakazu Kawashita, Toshiki Miyazaki, Masanobu Kamitakahara, Koji Ioku, Hiroyasu Kanetaka (2012) Comparison of Adsorption Behavior of Bovine Serum Albumin and Osteopontin of hydroxyapatite and Alumina. Phosphorus Research Bulletin 26: 23-28

     

23. Masanobu Kamitakahara, Ryosuke Fujii, Koji Ioku (2012) Techniques for Preparing Pure β-Tricalcium Phosphate Granules Composed of Rod-shaped Particles. Phosphorus Research Bulletin 26: 29-32

     

24. Cem Bulent USTUNDAG, Figen KAYA, Masanobu KAMITAKAHARA, Cengiz KAYA, Koji IOKU (2012) Production of tubular porous hydroxyapatite using electrophoretic deposition. J. Ceram. Soc. Japan 120 [12]: 569-573

     

25. Tohru Ikeda, Yoshinori Gonda, Eri Tatsukawa, Yasuaki Shibata, Masanobu Kamitakahara, Takatoshi Okuda, Ikuho Yonezawa, Hisashi Kurosawa,Koji Ioku (2012) Stimulation of Osteogenesis in Bone Defects Implanted with Biodegradable Hydroxyapatite Composed of Rod-Shaped Particles under Mechanical Unloading. Acta Histochem. Cytochem 45 [5]: 283-292

     

26. 井奥洪二, 上高原理暢, 池田 通 (Koji Ioku, Masanobu Kamitakahara, Tohru Ikeda) (2012) 骨代謝に組み込まれる水酸アパタイト多孔体 (Porous Hydroxyapatite Built into the Bone Metabolism.) J. Inorg. Mater. Japan 19: 396-400

Profile

Dr. Ioku is a professor in the Faculty of Economics, Keio University, Japan. He received his Doctorate of Science in Engineering from the Tokyo Institute of Technology in 1990. From 1989 to 1993 he worked as an assistant professor in the Faculty of Science at Kochi University. He was promoted to associate professor of the Faculty of Engineering (1993-2001), the Graduate School of Medicine (2001-2003) at Yamaguchi University, and the Graduate School of Environmental Studies at Tohoku University (2003-2006). From 2006 he held a professorship at Tohoku University and moved to Keio University in April 2012. Dr. Ioku is an active member of several professional associations, such as the Ceramic Society of Japan, the Materials Research Society of Japan, the International Society for Ceramics in Medicine.
He has received numerous awards for his scientific achievements, including from the MRS International Meeting (1988), the Japanese Association of Inorganic Phosphorus Chemistry (1996; 2008), the Society of Inorganic Materials Japan (2000), the Asian BioCeramics Society (2005), and the Ceramic Society of Japan (2009). He has also published around 300 peer-reviewed papers in the fields of materials science, medical science, and environmental science.